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Make and model	Body type	Size	Power	Top Speed	Acceleration	Production
Mercedes-Benz S-klasse V (W221) 550 5.5 automatic (388 bhp) 4WD Long	Sedan	5461 cc 5.5 litre	388 bhp 285 kW	155 mph 250 kph	5.4 sec	2005 - 2009
Mercedes-Benz S-klasse V (W221) 550 5.5 automatic (388 bhp) Long	Sedan	5461 cc 5.5 litre	388 bhp 285 kW	155 mph 250 kph	5.4 sec	2005 - 2009
Mercedes-Benz S-klasse V (W221) 600 5.5 automatic (517 bhp) Long	Sedan	5513 cc 5.5 litre	517 bhp 380 kW	155 mph 250 kph	4.6 sec	2005 - 2009
Mercedes-Benz S-klasse V (W221) 63 AMG 6.2 automatic (525 bhp)	Sedan	6208 cc 6.2 litre	525 bhp 386 kW	155 mph 250 kph	4.6 sec	2006 - 2009
Mercedes-Benz S-klasse V (W221) 63 AMG 6.2 automatic (525 bhp) Long	Sedan	6208 cc 6.2 litre	525 bhp 386 kW	155 mph 250 kph	4.6 sec	2006 - 2009
Mercedes-Benz S-klasse V (W221) 65 AMG 6.0 automatic (612 bhp) Long	Sedan	5980 cc 6 litre	612 bhp 450 kW	155 mph 250 kph	4.4 sec	2006 - 2009
Mercedes-Benz S-klasse V (W221) Pullman 6.2 automatic (525 bhp)	Limousine	6208 cc 6.2 litre	525 bhp 386 kW			2006 - 2009
Mercedes-Benz S-klasse V (W221) Facelift 300 3.0 automatic (231 bhp)	Sedan	2996 cc 3 litre	231 bhp 170 kW	155 mph 250 kph	8.2 sec	2009 - 2013
Mercedes-Benz S-klasse V (W221) Facelift 300 3.0 automatic (231 bhp) Long	Sedan	2996 cc 3 litre	231 bhp 170 kW	155 mph 250 kph	8.2 sec	2009 - 2013
Mercedes-Benz S-klasse V (W221) Facelift 350 3.0d automatic (235 bhp)	Sedan	2987 cc 3 litre	235 bhp 173 kW	155 mph 250 kph	7.5 sec	2009 - 2013
Mercedes-Benz S-klasse V (W221) Facelift 350 3.0d automatic (235 bhp) 4WD	Sedan	2987 cc 3 litre	235 bhp 173 kW	155 mph 250 kph		2009 - 2013
Mercedes-Benz S-klasse V (W221) Facelift 350 3.0d automatic (235 bhp) 4WD Long	Sedan	2987 cc 3 litre	235 bhp 173 kW	155 mph 250 kph		2009 - 2013
Mercedes-Benz S-klasse V (W221) Facelift 350 3.0d automatic (235 bhp) Long	Sedan	2987 cc 3 litre	235 bhp 173 kW	155 mph 250 kph	7.8 sec	2009 - 2013
Mercedes-Benz S-klasse V (W221) Facelift 400 3.5hyb automatic (299 bhp)	Sedan	3498 cc 3.5 litre	299 bhp 220 kW	155 mph 250 kph	7.2 sec	2009 - 2013
Mercedes-Benz S-klasse V (W221) Facelift 400 3.5hyb automatic (299 bhp) Long	Sedan	3498 cc 3.5 litre	299 bhp 220 kW	155 mph 250 kph	7.2 sec	2009 - 2013
Mercedes-Benz S-klasse V (W221) Facelift 450 4.0d automatic (320 bhp)	Sedan	3996 cc 4 litre	320 bhp 235 kW	155 mph 250 kph	6.6 sec	2009 - 2013
Mercedes-Benz S-klasse V (W221) Facelift 500 4.7 automatic (435 bhp) 4WD Long	Sedan	4663 cc 4.7 litre	435 bhp 320 kW	155 mph 250 kph	5 sec	2009 - 2013
Mercedes-Benz S-klasse V (W221) Facelift 500 4.7 automatic (435 bhp) Long	Sedan	4663 cc 4.7 litre	435 bhp 320 kW	155 mph 250 kph	5 sec	2009 - 2013
Mercedes-Benz S-klasse V (W221) Facelift 600 5.5 automatic (517 bhp) Long	Sedan	5513 cc 5.5 litre	517 bhp 380 kW	155 mph 250 kph	4.6 sec	2009 - 2013
Mercedes-Benz S-klasse V (W221) Facelift 63 AMG 5.5 automatic (544 bhp) Long	Sedan	5461 cc 5.5 litre	544 bhp 400 kW	155 mph 250 kph	4.5 sec	2009 - 2013